Relationship between Striatal Dopamine Function and Hippocampal Glutamate Levels in Subjects at Ultra High Risk of Psychosis
نویسندگان
چکیده
Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections.
منابع مشابه
Neural and Behavioral Correlates of Aberrant Salience in Individuals at Risk for Psychosis
The "aberrant salience" model proposes that psychotic symptoms first emerge when chaotic brain dopamine transmission leads to the attribution of significance to stimuli that would normally be considered irrelevant. This is thought to occur during the prodromal phase of psychotic disorders, but this prediction has not been tested previously. In the present study, we tested this model in 18 healt...
متن کاملFunctional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation.
Little is known about the neurobiological factors that determine functional outcome in people at high risk for psychosis. We use multimodal neuroimaging to investigate whether cortical responses during a cognitive task and thalamic glutamate levels were associated with subsequent functional outcome. Sixty subjects participated: 27 healthy controls (CTRL) and 33 at ultrahigh risk (UHR) for psych...
متن کاملAdversity in childhood linked to elevated striatal dopamine function in adulthood
Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animal models suggest that this effect may be mediated by increased striatal dopamine neurotransmission. The primary objective of this study was to examine the relationship between adversity in childhood and striatal dopamine function in early adulthood. Secondary objectives were to compare exposure to childhood a...
متن کاملAbnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study.
CONTEXT Alterations in dopaminergic neurotransmission and function of the prefrontal cortex are thought to be central to the pathophysiology of schizophrenia, but the relationship between these factors in the development of psychosis is unclear. OBJECTIVE To investigate the relationship between striatal dopamine activity and prefrontal function in people at ultra high risk of psychosis. DES...
متن کاملCortico-Striatal GABAergic and Glutamatergic Dysregulations in Subjects at Ultra-High Risk for Psychosis Investigated with Proton Magnetic Resonance Spectroscopy
BACKGROUND Dysregulations of the major inhibitory and excitatory amino neurotransmitter systems of γ-aminobutyric acid and glutamate, respectively, have been described in patients with schizophrenia. However, it is unclear whether these abnormalities are present in subjects at ultra-high risk for psychosis. METHODS Twenty-three antipsychotic naïve subjects at ultra-high risk and 24 healthy co...
متن کامل